the sample is introduced through the injector. The mobile phase brings the sample into the chromatographic column. In the chromatographic column, each component is separated due to the different partition coefficient or adsorption force in the stationary phase.
Thep principle diagram is as shown in the figure. The infusion pump delievers mobile phase (or pressure) to the analysis system at a stable flow rate (or pressure). The sampler carries the sample into the column, then mobile phase brings the sample into the column. The components in the column are separated by their distribution coefficients or adsorbability in the fixed phase and flow to the TOF ion source with the mobile phase in turn. An ion source converts a sample in the liquid phase into ions in the gas phase, through the introduction of MS interface into the TOF detector, and the detected signals are sent to the data system for recording, processing, or storage.